Entehep tablet, a antiviral drug which used for liver diseases, hepatitis B virus infected to HIV patients, liver infection. Entecavir is a film coated tablet. Entehep is an nucleotide polymerase analogue which used to treat the HBV, HCV, herpes simplex and HIV infections. When the drug is phosphorylated, they work as a antimetabolitie same to nucleotides to be confine into DNA strands growth, but they also act as chain terminators and stops the DNA viral polymerase.
Entecavir may also control the all 3 steps of multiplication process:
Appropriate RNA messenger produce negative strand of reverse transcription
Synthesis of positive strand of hepatitis B virus DNA
No specific action of DNA viral and also inhibits mitochondrial DNA. Entecavir reduces the amount of HBV in the blood by decreasing the ability to replication and affects new cells.
The recommended dose is 0.5mg & 1mg for adult Every day, once daily in an empty stomach ( 2hours before or after food) at same time. Duration of course (Entecavir dose) discontinue means, infection may get worst.
In adult and children < 2yrs, X vir mainly used for treatment of long lasting Hepatitis B infection. The infection caused by Hepatitis B virus in liver. This infection will damage the liver and cause liver failure or liver cancer. The reducing of hepatitis B virus quantity in body is carried out by X vir tablet.
Entecavir, after liver transplantation the replication of HBV is prevented. X vir is used for the selected for resistance to lamivudine and emtricitabine in HIV, hence its not prescribed for both HIV-HBV patient without fully stopping X vir drug.
Entehep co administration other drugs( lamivudine, adefovir, dipivoxil, or tenofovir) will result no drug interaction and affect the renal function, hence patient should be monitored regularily.
The patient who discontinue the anti hepatitis treatment should check the hepatic function follow up closely then restart of anti viral drug may be warned.
Pregnancy category C, pregnant women or planning for pregnancy and male sexual partner should inform doctor pirorly to usage of entehep because no appropriate and well defined studies of entehep in pregnant women. Similar for breast feeding. Unknown whether entehep excreted into human milk its affect adverse reaction for new born.
Entecavir Involves side effects :
• Head pain
• Nausea & Vomiting
• low heartbeat
• Light Headedness
• pain in stomach
• Muscle ache
• Cold Legs
• weight loss
• Yellow colour change in Skin And Urine
• Dyspnea, Dizziness.
If Entehep overdose, Inform to emergency department in hospital or poison control center to avoid accident.
Store at 22-25°C ( 77°F )
Entehep store at light and moisture resistance
Store at reach out of children and pets.
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